pentobarbital will decrease the level or impact of buprenorphine buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will decrease the level or result of buprenorphine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Observe Closely (one)pentobarbital will minimize